Does Berotralstat Hydrochloride Interact with Desogestrel?
Berotralstat Hydrochloride and Desogestrel have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use increases exposure to etonogestrel (active metabolite of desogestrel) and may increase risk of desogestrel-associated adverse reactions. Consider benefits and risks. The mechanism involves orladeyo inhibits metabolism of desogestrel to etonogestrel. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Berotralstat Hydrochloride and Desogestrel occurs because orladeyo inhibits metabolism of desogestrel to etonogestrel. Clinically, this means concomitant use increases exposure to etonogestrel (active metabolite of desogestrel) and may increase risk of desogestrel-associated adverse reactions. consider benefits and risks. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Berotralstat Hydrochloride and your doctor is considering prescribing Desogestrel (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider