Does Buprenorphine Interact with Mao Inhibitors?
Buprenorphine and Mao Inhibitors have a moderate drug interaction according to U.S. FDA drug labeling data. Can increase plasma concentration of buprenorphine, resulting in increased or prolonged opioid effects; discontinuation may result in decreased efficacy or withdrawal. The mechanism involves inhibition of cyp3a4 metabolism increases buprenorphine plasma concentration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Buprenorphine Class
- Partial Opioid Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Buprenorphine and Mao Inhibitors occurs because inhibition of cyp3a4 metabolism increases buprenorphine plasma concentration. Clinically, this means can increase plasma concentration of buprenorphine, resulting in increased or prolonged opioid effects; discontinuation may result in decreased efficacy or withdrawal. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Buprenorphine and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider