Does Busulfan Interact with Acetaminophen?
Busulfan and Acetaminophen have a moderate drug interaction according to U.S. FDA drug labeling data. Use within 72 hours prior to or concurrent with busulfan may result in reduced busulfan clearance by decreasing glutathione levels. The mechanism involves decreases glutathione levels, which busulfan requires for elimination via conjugation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Busulfan Class
- Alkylating Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Busulfan and Acetaminophen occurs because decreases glutathione levels, which busulfan requires for elimination via conjugation. Clinically, this means use within 72 hours prior to or concurrent with busulfan may result in reduced busulfan clearance by decreasing glutathione levels. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Busulfan and your doctor is considering prescribing Acetaminophen (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider