Does Cangrelor Interact with Clopidogrel?
CDI records a contraindicated classification for Cangrelor and Clopidogrel. The stored summary is: Do not administer during cangrelor infusion. Clopidogrel will have no antiplatelet effect until the next dose is administered after cangrelor infusion is discontinued. The mechanism involves cangrelor infusion prevents antiplatelet effect of clopidogrel. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Cangrelor Class
- P2Y12 Platelet Inhibitor
- Clopidogrel Class
- P2Y12 Platelet Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cangrelor infusion prevents antiplatelet effect of clopidogrel
What To Tell Your Doctor or Pharmacist
If you are taking Cangrelor and your doctor is considering prescribing Clopidogrel (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider