Home›Bupropion Hcl Er›Bupropion Hcl Er + Clopidogrel

Does Bupropion Hcl Er Interact with Clopidogrel?

CDI records a contraindicated classification for Bupropion Hcl Er and Clopidogrel. The stored summary is: Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure. The mechanism involves cyp2b6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Contraindicated
Clopidogrel Class: P2Y12 Platelet Inhibitor
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

CYP2B6 inhibition

What To Tell Your Doctor or Pharmacist

If you are taking Bupropion Hcl Er and your doctor is considering prescribing Clopidogrel (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Bupropion Hcl Er(Bupropion Hcl Er (Xl))+💊 Clopidogrel(Plavix)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

CDI classifies this record as contraindicated. Confirm the applicable product labeling with your prescriber or pharmacist.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

P2Y12 Platelet Inhibitor

Source

NLP:bupropion hcl er

What this means in plain English

Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure.

About Bupropion Hcl Er and Clopidogrel

Clopidogrel is a P2Y12 Platelet Inhibitor. Clopidogrel is also sold under the brand name Plavix. Both Bupropion Hcl Er and Clopidogrel carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:bupropion hcl er

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.