Does Carbamazepine Interact with Lamotrigine Chewable Dispersible?
CDI records a moderate classification for Carbamazepine and Lamotrigine Chewable Dispersible. The stored summary is: Addition of carbamazepine decreases lamotrigine concentration approximately 40%. May increase carbamazepine epoxide levels. The mechanism involves carbamazepine induces lamotrigine glucuronidation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Carbamazepine Class
- Mood Stabilizer
- Lamotrigine Chewable Dispersible Class
- Anti-epileptic Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Carbamazepine induces lamotrigine glucuronidation
What To Tell Your Doctor or Pharmacist
If you are taking Carbamazepine and your doctor is considering prescribing Lamotrigine Chewable Dispersible (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider