Does Carbidopa Interact with Tolcapone?
CDI records a minor classification for Carbidopa and Tolcapone. The stored summary is: No effects on pharmacokinetics of carbidopa observed despite tolcapone's potential to influence COMT substrate metabolism. The mechanism involves comt metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Minor
- Carbidopa Class
- Aromatic Amino Acid Decarboxylation Inhibitor
- Tolcapone Class
- Catechol-O-Methyltransferase Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
COMT metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Carbidopa and your doctor is considering prescribing Tolcapone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider