Does Tolcapone Interact with Levodopa?
Tolcapone and Levodopa have a moderate drug interaction according to U.S. FDA drug labeling data. When combined with tolcapone and desipramine, frequency of adverse events increased slightly. Caution advised due to additive effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tolcapone Class
- Catechol-O-Methyltransferase Inhibitor
- Levodopa Class
- Aromatic Amino Acid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Tolcapone and your doctor is considering prescribing Levodopa (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider