Does Carbidopa Levodopa And Entacapone Interact with Coumadin?
Carbidopa Levodopa And Entacapone and Coumadin have a moderate drug interaction according to U.S. FDA drug labeling data. Dose adjustment may be required; monitor INR when initiating carbidopa, levodopa and entacapone in patients on coumadin. The mechanism involves cyp2c9 metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Carbidopa Levodopa And Entacapone Class
- Aromatic Amino Acid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Carbidopa Levodopa And Entacapone and Coumadin occurs because cyp2c9 metabolism. Clinically, this means dose adjustment may be required; monitor inr when initiating carbidopa, levodopa and entacapone in patients on coumadin. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Carbidopa Levodopa And Entacapone and your doctor is considering prescribing Coumadin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider