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Does Carbidopa Levodopa And Entacapone Interact with Mao Inhibitors?

Carbidopa Levodopa And Entacapone and Mao Inhibitors have a contraindicated drug interaction according to U.S. FDA drug labeling data. Increased adrenergic tone risk. Use is contraindicated in patients receiving nonselective MAO inhibitors. The mechanism involves increased adrenergic tone. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Carbidopa Levodopa And Entacapone Class
Aromatic Amino Acid
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Carbidopa Levodopa And Entacapone and Mao Inhibitors occurs because increased adrenergic tone. Clinically, this means increased adrenergic tone risk. use is contraindicated in patients receiving nonselective mao inhibitors. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Carbidopa Levodopa And Entacapone and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Carbidopa Levodopa And Entacapone(Carbidopa, Levodopa And Entacapone)+💊 Mao Inhibitors

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Aromatic Amino Acid
Drug B class
—
Source
NLP:carbidopa, levodopa and entacapone

What this means in plain English

Increased adrenergic tone risk. Use is contraindicated in patients receiving nonselective MAO inhibitors.

What the FDA label says

"Increased adrenergic tone"

📖 Source: NLP:carbidopa, levodopa and entacapone

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.