Does Carvedilol Interact with Cinacalcet?
Carvedilol and Cinacalcet have a moderate drug interaction according to U.S. FDA drug labeling data. CYP2D6 substrate; cinacalcet is a strong CYP2D6 inhibitor. Dose adjustment may be required for concomitant CYP2D6-metabolized medications. The mechanism involves cinacalcet inhibits cyp2d6, increasing carvedilol levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Carvedilol Class
- alpha-Adrenergic Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Carvedilol and Cinacalcet occurs because cinacalcet inhibits cyp2d6, increasing carvedilol levels. Clinically, this means cyp2d6 substrate; cinacalcet is a strong cyp2d6 inhibitor. dose adjustment may be required for concomitant cyp2d6-metabolized medications. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Carvedilol and your doctor is considering prescribing Cinacalcet (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider