Does Ceftazidime Avibactam Interact with Probenecid?
Ceftazidime Avibactam and Probenecid have a moderate drug interaction according to U.S. FDA drug labeling data. Probenecid inhibits OAT-mediated uptake of avibactam by 56-70% in vitro, potentially decreasing avibactam elimination. Co-administration is not recommended due to lack of clinical data. The mechanism involves inhibition of oat1 and oat3 transporters, reducing avibactam renal excretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ceftazidime Avibactam and Probenecid occurs because inhibition of oat1 and oat3 transporters, reducing avibactam renal excretion. Clinically, this means probenecid inhibits oat-mediated uptake of avibactam by 56-70% in vitro, potentially decreasing avibactam elimination. co-administration is not recommended due to lack of clinical data. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ceftazidime Avibactam and your doctor is considering prescribing Probenecid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider