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Chlorothiazide Sodium

Also known as: Chlorothiazide Sodium

Route: Intravenous

Check Chlorothiazide Sodium Interactions →

13 interactions on record

Chlorothiazide Sodium has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Corticosteroids, Repository Corticotropin. Patients taking Chlorothiazide Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 13
Contraindicated: 1
Major: 2
Moderate: 9

Contraindicated (1)

Chlorothiazide Sodium + Lithium— Lithium generally should not be given with chlorothiazide sodium. Diuretics reduce renal clearance of lithium and add hi…

Major (2)

Chlorothiazide Sodium + Corticosteroids— Intensified electrolyte depletion, particularly hypokalemia, may occur when corticosteroids are given with chlorothiazid…
Chlorothiazide Sodium + Repository Corticotropin— Intensified electrolyte depletion, particularly hypokalemia, may occur when ACTH is given with chlorothiazide sodium.

Moderate (9)

Chlorothiazide Sodium + Acidifying Agents— Dosage adjustment of oral antidiabetic agents may be required when used concurrently with chlorothiazide sodium.
Chlorothiazide Sodium + Alcohol— Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide sodium.
Chlorothiazide Sodium + Barbiturates— Potentiation of orthostatic hypotension may occur when barbiturates are given concurrently with chlorothiazide sodium.
Chlorothiazide Sodium + Insulin Degludec And Liraglutide— Dosage adjustment of the antidiabetic drug may be required when used concurrently with chlorothiazide sodium.
Chlorothiazide Sodium + Insulin Human— Dosage adjustment of insulin may be required when used concurrently with chlorothiazide sodium.
Chlorothiazide Sodium + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIDs can reduce the diuretic, natriuretic, and antihypertensive effects of chlorothiazide sodium. Patient should be cl…
Chlorothiazide Sodium + Norepinephrine— Possible decreased response to norepinephrine when used concurrently with chlorothiazide sodium, but not sufficient to p…
Chlorothiazide Sodium + Other Anticholinergic Agents— Additive effect or potentiation of antihypertensive response may occur with concurrent use of chlorothiazide sodium.
Chlorothiazide Sodium + Tubocurarine— Possible increased responsiveness to tubocurarine when used concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Lithium⛔Contraindicated

Lithium generally should not be given with chlorothiazide sodium. Diuretics reduce renal clearance of lithium and add high risk of lithium toxicity.

Chlorothiazide Sodium + Corticosteroids⚠️Major

Intensified electrolyte depletion, particularly hypokalemia, may occur when corticosteroids are given with chlorothiazide sodium.

Chlorothiazide Sodium + Repository Corticotropin⚠️Major

Intensified electrolyte depletion, particularly hypokalemia, may occur when ACTH is given with chlorothiazide sodium.

Chlorothiazide Sodium + Acidifying Agents🟡Moderate

Dosage adjustment of oral antidiabetic agents may be required when used concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Alcohol🟡Moderate

Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Barbiturates🟡Moderate

Potentiation of orthostatic hypotension may occur when barbiturates are given concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Insulin Degludec And Liraglutide🟡Moderate

Dosage adjustment of the antidiabetic drug may be required when used concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Insulin Human🟡Moderate

Dosage adjustment of insulin may be required when used concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)🟡Moderate

NSAIDs can reduce the diuretic, natriuretic, and antihypertensive effects of chlorothiazide sodium. Patient should be closely observed to determine if desired diuretic effect is obtained.

Chlorothiazide Sodium + Norepinephrine🟡Moderate

Possible decreased response to norepinephrine when used concurrently with chlorothiazide sodium, but not sufficient to preclude use.

Chlorothiazide Sodium + Other Anticholinergic Agents🟡Moderate

Additive effect or potentiation of antihypertensive response may occur with concurrent use of chlorothiazide sodium.

Chlorothiazide Sodium + Tubocurarine🟡Moderate

Possible increased responsiveness to tubocurarine when used concurrently with chlorothiazide sodium.

Chlorothiazide Sodium + Chlorothiazideℹ️Unknown

Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide sodium. Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.