Does Cholic Acid Interact with Fenofibric Acid?
Cholic Acid and Fenofibric Acid have a moderate drug interaction according to U.S. FDA drug labeling data. Bile-acid binding resins may bind fenofibric acid concurrently. Administer fenofibric acid at least 1 hour before or 4-6 hours after the bile acid resin to avoid impeding absorption. The mechanism involves concurrent drug binding by bile-acid binding resins. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Cholic Acid Class
- Bile Acid
- Fenofibric Acid Class
- Peroxisome Proliferator Receptor alpha Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cholic Acid and Fenofibric Acid occurs because concurrent drug binding by bile-acid binding resins. Clinically, this means bile-acid binding resins may bind fenofibric acid concurrently. administer fenofibric acid at least 1 hour before or 4-6 hours after the bile acid resin to avoid impeding absorption. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Cholic Acid and your doctor is considering prescribing Fenofibric Acid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider