Does Clonazepam Interact with Lamotrigine?
CDI records a major classification for Clonazepam and Lamotrigine. The stored summary is: Lamotrigine induces clonazepam metabolism, causing approximately 38% decrease in plasma clonazepam levels. The mechanism involves cyp450 induction of clonazepam metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Clonazepam Class
- Benzodiazepine
- Lamotrigine Class
- Anti-epileptic Agent
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP450 induction of clonazepam metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Clonazepam and your doctor is considering prescribing Lamotrigine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider