Does Clonidine Interact with Metoprolol Succinate Er?
CDI records a major classification for Clonidine and Metoprolol Succinate Er. The stored summary is: Concomitant use increases bradycardia risk. Withdraw beta-blocker several days before clonidine withdrawal to avoid rebound hypertension exacerbation. The mechanism involves additive atrioventricular conduction slowing; beta-blockers exacerbate clonidine withdrawal rebound hypertension. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Clonidine Class
- Central alpha-2 Adrenergic Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive atrioventricular conduction slowing; beta-blockers exacerbate clonidine withdrawal rebound hypertension
What To Tell Your Doctor or Pharmacist
If you are taking Clonidine and your doctor is considering prescribing Metoprolol Succinate Er (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider