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Does Cyclophosphamide Interact with Succinylcholine?

Cyclophosphamide and Succinylcholine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity. Prolonged apnea may occur with concurrent depolarizing muscle relaxants within 10 days of treatment. The mechanism involves marked and persistent inhibition of cholinesterase activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Cyclophosphamide Class
Alkylating Drug
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cyclophosphamide and Succinylcholine occurs because marked and persistent inhibition of cholinesterase activity. Clinically, this means cyclophosphamide causes marked and persistent inhibition of cholinesterase activity. prolonged apnea may occur with concurrent depolarizing muscle relaxants within 10 days of treatment. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Cyclophosphamide and your doctor is considering prescribing Succinylcholine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cyclophosphamide+💊 Succinylcholine(Succinylcholine)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Alkylating Drug
Drug B class
—
Source
NLP:cyclophosphamide

What this means in plain English

Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity. Prolonged apnea may occur with concurrent depolarizing muscle relaxants within 10 days of treatment.

What the FDA label says

"Marked and persistent inhibition of cholinesterase activity"

📖 Source: NLP:cyclophosphamide

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.