Does Cytochrome P450 Metabolized Drugs Interact with Somatropin?
Cytochrome P450 Metabolized Drugs and Somatropin have a moderate drug interaction according to U.S. FDA drug labeling data. Somatropin may alter clearance of CYP450-metabolized compounds including corticosteroids, sex steroids, anticonvulsants, and cyclosporine. Careful monitoring recommended. The mechanism involves somatropin increases cyp450-mediated antipyrine clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Somatropin Class
- Recombinant Human Growth Hormone
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cytochrome P450 Metabolized Drugs and Somatropin occurs because somatropin increases cyp450-mediated antipyrine clearance. Clinically, this means somatropin may alter clearance of cyp450-metabolized compounds including corticosteroids, sex steroids, anticonvulsants, and cyclosporine. careful monitoring recommended. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Cytochrome P450 Metabolized Drugs and your doctor is considering prescribing Somatropin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider