Does Somatropin Interact with Prednisone?
CDI records a major classification for Somatropin and Prednisone. The stored summary is: Somatropin inhibits conversion of prednisone to its active metabolite. Patients may require increased maintenance or stress doses. The mechanism involves inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11βhsd-1). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Somatropin Class
- Recombinant Human Growth Hormone
- Prednisone Class
- Corticosteroid
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD-1)
What To Tell Your Doctor or Pharmacist
If you are taking Somatropin and your doctor is considering prescribing Prednisone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider