Does Deferiprone Interact with Diclofenac?
Deferiprone and Diclofenac have a major drug interaction according to U.S. FDA drug labeling data. UGT1A6 inhibitor; avoid co-administration with FERRIPROX. The mechanism involves inhibition of udp-glucuronosyltransferase 1a6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Deferiprone Class
- Iron Chelator
- Diclofenac Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Deferiprone and Diclofenac occurs because inhibition of udp-glucuronosyltransferase 1a6. Clinically, this means ugt1a6 inhibitor; avoid co-administration with ferriprox. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Deferiprone and your doctor is considering prescribing Diclofenac (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider