Home›Dichlorphenamide›Dichlorphenamide + Metformin

Does Dichlorphenamide Interact with Metformin?

Dichlorphenamide and Metformin have a major drug interaction according to U.S. FDA drug labeling data. Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with metformin. The mechanism involves decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Dichlorphenamide Class
Carbonic Anhydrase Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Dichlorphenamide and Metformin occurs because decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis. Clinically, this means carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with metformin. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Dichlorphenamide and your doctor is considering prescribing Metformin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Dichlorphenamide+💊 Metformin(Metformin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Carbonic Anhydrase Inhibitor
Drug B class
—
Source
NLP:metformin

What this means in plain English

Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with metformin.

What the FDA label says

"Decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis"

📖 Source: NLP:metformin

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Dichlorphenamide and Metformin against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.