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Does Dichlorphenamide Interact with Acetylsalicylic Acid?

Dichlorphenamide and Acetylsalicylic Acid have a contraindicated drug interaction according to U.S. FDA drug labeling data. High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-dose aspirin requires careful monitoring. The mechanism involves dichlorphenamide causes metabolic acidosis, increasing salicylate toxicity risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Dichlorphenamide Class
Carbonic Anhydrase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Dichlorphenamide and Acetylsalicylic Acid occurs because dichlorphenamide causes metabolic acidosis, increasing salicylate toxicity risk. Clinically, this means high-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. low-dose aspirin requires careful monitoring. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Dichlorphenamide and your doctor is considering prescribing Acetylsalicylic Acid (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Dichlorphenamide+💊 Acetylsalicylic Acid

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Carbonic Anhydrase Inhibitor
Drug B class
—
Source
NLP:dichlorphenamide

What this means in plain English

High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-dose aspirin requires careful monitoring.

What the FDA label says

"Dichlorphenamide causes metabolic acidosis, increasing salicylate toxicity risk"

📖 Source: NLP:dichlorphenamide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.