Does Digitoxin Interact with Trandolapril And Verapamil Hydrochloride?
Digitoxin and Trandolapril And Verapamil Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. Verapamil reduces total body clearance and extrarenal clearance of digitoxin by 27% and 29%, respectively, risking toxicity. The mechanism involves reduced digitoxin clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Trandolapril And Verapamil Hydrochloride Class
- Angiotensin Converting Enzyme Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Digitoxin and Trandolapril And Verapamil Hydrochloride occurs because reduced digitoxin clearance. Clinically, this means verapamil reduces total body clearance and extrarenal clearance of digitoxin by 27% and 29%, respectively, risking toxicity. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Digitoxin and your doctor is considering prescribing Trandolapril And Verapamil Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider