Does Digoxin Interact with Eliglustat?
Digoxin and Eliglustat have a moderate drug interaction according to U.S. FDA drug labeling data. Eliglustat may increase digoxin concentrations as a P-gp substrate. Monitor serum digoxin and reduce dose by 30% before initiating eliglustat. The mechanism involves eliglustat inhibits p-glycoprotein-mediated digoxin transport. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Digoxin Class
- Cardiac Glycoside
- Eliglustat Class
- Glucosylceramide Synthase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Digoxin and Eliglustat occurs because eliglustat inhibits p-glycoprotein-mediated digoxin transport. Clinically, this means eliglustat may increase digoxin concentrations as a p-gp substrate. monitor serum digoxin and reduce dose by 30% before initiating eliglustat. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Digoxin and your doctor is considering prescribing Eliglustat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider