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Does Doxorubicin Interact with Abacavir Lamivudine And Zidovudine?

Doxorubicin and Abacavir Lamivudine And Zidovudine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship. The mechanism involves antagonistic relationship demonstrated in vitro. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Abacavir Lamivudine And Zidovudine Class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Doxorubicin and Abacavir Lamivudine And Zidovudine occurs because antagonistic relationship demonstrated in vitro. Clinically, this means concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Doxorubicin and your doctor is considering prescribing Abacavir Lamivudine And Zidovudine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Doxorubicin(Doxorubicin Hydrochloride)+💊 Abacavir Lamivudine And Zidovudine(Abacavir, Lamivudine And Zidovudine)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Source
NLP:abacavir , lamivudine and zidovudine

What this means in plain English

Concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship.

What the FDA label says

"Antagonistic relationship demonstrated in vitro"

📖 Source: NLP:abacavir , lamivudine and zidovudine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.