Does Drugs Metabolized By Cyp2d6 Interact with Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide?
Drugs Metabolized By Cyp2d6 and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration may result in increased plasma concentrations of CYP3A substrates, which could increase or prolong their therapeutic effect and adverse events. The mechanism involves darunavir and cobicistat inhibit cyp3a metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Drugs Metabolized By Cyp2d6 and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide occurs because darunavir and cobicistat inhibit cyp3a metabolism. Clinically, this means co-administration may result in increased plasma concentrations of cyp3a substrates, which could increase or prolong their therapeutic effect and adverse events. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Drugs Metabolized By Cyp2d6 and your doctor is considering prescribing Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider