Does Drugs Metabolized By Cyp2d6 Interact with Interferon Gamma 1b?
Drugs Metabolized By Cyp2d6 and Interferon Gamma 1b have a moderate drug interaction according to U.S. FDA drug labeling data. INTERFERON GAMMA-1B may decrease hepatic metabolism via reduced cytochrome P-450 concentrations, potentially increasing drug levels. The mechanism involves depression of hepatic p-450 metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Interferon Gamma 1b Class
- Interferon gamma
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Drugs Metabolized By Cyp2d6 and Interferon Gamma 1b occurs because depression of hepatic p-450 metabolism. Clinically, this means interferon gamma-1b may decrease hepatic metabolism via reduced cytochrome p-450 concentrations, potentially increasing drug levels. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Drugs Metabolized By Cyp2d6 and your doctor is considering prescribing Interferon Gamma 1b (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider