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Does Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers Interact with Roflumilast?

Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers and Roflumilast have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration may increase roflumilast systemic exposure and may result in increased adverse reactions. Weigh potential for increased adverse reactions against benefit. The mechanism involves cyp3a4 and cyp1a2 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Roflumilast Class
Phosphodiesterase 4 Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers and Roflumilast occurs because cyp3a4 and cyp1a2 inhibition. Clinically, this means co-administration may increase roflumilast systemic exposure and may result in increased adverse reactions. weigh potential for increased adverse reactions against benefit. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers and your doctor is considering prescribing Roflumilast (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers(Vagistat)+💊 Roflumilast(Daliresp)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Phosphodiesterase 4 Inhibitor
Source
NLP:roflumilast

What this means in plain English

Co-administration may increase roflumilast systemic exposure and may result in increased adverse reactions. Weigh potential for increased adverse reactions against benefit.

About Dual Strong Cyp3a4 Moderate Cyp1a2 Inducers and Roflumilast

Roflumilast is a Phosphodiesterase 4 Inhibitor. You may recognize them by the brand names Vagistat and Daliresp. Roflumilast is taken by mouth.

What the FDA label says

"CYP3A4 and CYP1A2 inhibition"

📖 Source: NLP:roflumilast

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.