Does Elafibranor Interact with Rifampin?
Elafibranor and Rifampin have a moderate drug interaction according to U.S. FDA drug labeling data. Rifampin induces metabolizing enzymes, reducing systemic exposure of elafibranor and its active metabolite, potentially resulting in delayed or suboptimal biochemical response. The mechanism involves enzyme induction increasing metabolism of elafibranor. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Elafibranor Class
- Peroxisome Proliferator-activated Receptor Agonist
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Elafibranor and Rifampin occurs because enzyme induction increasing metabolism of elafibranor. Clinically, this means rifampin induces metabolizing enzymes, reducing systemic exposure of elafibranor and its active metabolite, potentially resulting in delayed or suboptimal biochemical response. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Elafibranor and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider