Home›Enalapril Maleate And Hydrochlorothiazide›Enalapril Maleate And Hydrochlorothiazide + Aliskiren

Does Enalapril Maleate And Hydrochlorothiazide Interact with Aliskiren?

Enalapril Maleate And Hydrochlorothiazide and Aliskiren have a contraindicated drug interaction according to U.S. FDA drug labeling data. Contraindicated in patients with diabetes; avoid in patients with renal impairment (GFR <60 mL/min). Associated with increased risks of hypotension, hyperkalemia, and acute renal failure. The mechanism involves dual blockade of the renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Enalapril Maleate And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Enalapril Maleate And Hydrochlorothiazide and Aliskiren occurs because dual blockade of the renin-angiotensin system. Clinically, this means contraindicated in patients with diabetes; avoid in patients with renal impairment (gfr <60 ml/min). associated with increased risks of hypotension, hyperkalemia, and acute renal failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Enalapril Maleate And Hydrochlorothiazide and your doctor is considering prescribing Aliskiren (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Enalapril Maleate And Hydrochlorothiazide(Enalapril Maleate And Hydrochlorothiazide)+💊 Aliskiren(Aliskiren)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
—
Source
NLP:enalapril maleate and hydrochlorothiazide

What this means in plain English

Contraindicated in patients with diabetes; avoid in patients with renal impairment (GFR <60 mL/min). Associated with increased risks of hypotension, hyperkalemia, and acute renal failure.

What the FDA label says

"Dual blockade of the renin-angiotensin system"

📖 Source: NLP:enalapril maleate and hydrochlorothiazide

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Enalapril Maleate And Hydrochlorothiazide and Aliskiren against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.