Itraconazole: Avoid coadministration of itraconazole with aliskiren [see Warnings and Precautions (5.7) and Clinical Pharmacology (12.3) ]. Cyclosporine or Itraconazole: Avoid concomitant use.
Source: FDA drug label - aliskiren
Aliskiren Interactions
Brand names: Aliskiren
3 interactions on record
Aliskiren + AldosteroneModerate
Dual Blockade of the Renin-Angiotensin-Aldosterone System (RAAS): The concomitant use of aliskiren with other agents acting on the RAAS such as ACEIs or ARBs is associated with an increased risk of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy.
Source: FDA drug label - aliskiren
Aliskiren + FurosemideModerate
Furosemide: Oral coadministration of aliskiren and furosemide reduced exposure to furosemide. Monitor diuretic effects when furosemide is coadministered with aliskiren.
Source: FDA drug label - aliskiren