Does Factor Ix Complex Concentrates Interact with Concizumab?
Factor Ix Complex Concentrates and Concizumab have a major drug interaction according to U.S. FDA drug labeling data. High and/or frequent doses increase risk of thromboembolism. Maximum dose of 100 units/kg within 24 hours recommended. Additive and synergistic increase in thrombin peak observed. The mechanism involves additive and synergistic increase in thrombin generation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Concizumab Class
- Tissue Factor Pathway Inhibitor Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Factor Ix Complex Concentrates and Concizumab occurs because additive and synergistic increase in thrombin generation. Clinically, this means high and/or frequent doses increase risk of thromboembolism. maximum dose of 100 units/kg within 24 hours recommended. additive and synergistic increase in thrombin peak observed. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Factor Ix Complex Concentrates and your doctor is considering prescribing Concizumab (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider