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Does Febuxostat Interact with Mercaptopurine?

Febuxostat and Mercaptopurine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Febuxostat is contraindicated in patients being treated with mercaptopurine. Concomitant administration could increase plasma concentrations resulting in severe toxicity. The mechanism involves febuxostat inhibits xanthine oxidase, which metabolizes mercaptopurine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Febuxostat Class
Xanthine Oxidase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Febuxostat and Mercaptopurine occurs because febuxostat inhibits xanthine oxidase, which metabolizes mercaptopurine. Clinically, this means febuxostat is contraindicated in patients being treated with mercaptopurine. concomitant administration could increase plasma concentrations resulting in severe toxicity. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Febuxostat and your doctor is considering prescribing Mercaptopurine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Febuxostat(Uloric)+💊 Mercaptopurine(Purixan)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Xanthine Oxidase Inhibitor
Drug B class
—
Source
NLP:febuxostat

What this means in plain English

Febuxostat is contraindicated in patients being treated with mercaptopurine. Concomitant administration could increase plasma concentrations resulting in severe toxicity.

About Febuxostat and Mercaptopurine

Febuxostat is a Xanthine Oxidase Inhibitor. You may recognize them by the brand names Uloric and Purixan. Both medications are taken by mouth. Febuxostat additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Febuxostat inhibits xanthine oxidase, which metabolizes mercaptopurine"

📖 Source: NLP:febuxostat

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.