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Does Fentanyl Transdermal Interact with Carbamazepine?

Fentanyl Transdermal and Carbamazepine have a major drug interaction according to U.S. FDA drug labeling data. CYP3A4 inducer; concomitant use can decrease plasma concentration of fentanyl, resulting in decreased efficacy or withdrawal syndrome. Stopping inducer may increase fentanyl levels causing serious respiratory depression. The mechanism involves cyp3a4 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Fentanyl Transdermal Class
Opioid Agonist
Carbamazepine Class
Mood Stabilizer
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Fentanyl Transdermal and Carbamazepine occurs because cyp3a4 induction. Clinically, this means cyp3a4 inducer; concomitant use can decrease plasma concentration of fentanyl, resulting in decreased efficacy or withdrawal syndrome. stopping inducer may increase fentanyl levels causing serious respiratory depression. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Fentanyl Transdermal and your doctor is considering prescribing Carbamazepine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fentanyl Transdermal(Fentanyl Transdermal)+💊 Carbamazepine(Carbamazepine)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Opioid Agonist
Drug B class
Mood Stabilizer
Source
NLP:fentanyl transdermal

What this means in plain English

CYP3A4 inducer; concomitant use can decrease plasma concentration of fentanyl, resulting in decreased efficacy or withdrawal syndrome. Stopping inducer may increase fentanyl levels causing serious respiratory depression.

What the FDA label says

"CYP3A4 induction"

📖 Source: NLP:fentanyl transdermal

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.