Fluvoxamine + Lidocaine Hydrochloride Interaction

Majorinteraction on record

Description

CYP1A2 inhibitor that increases lidocaine plasma AUC by 71% and Cmax by 22%, decreases clearance by 41%-60%, and prolongs half-life by one hour.

Mechanism

CYP1A2 inhibition decreases lidocaine clearance

Source: NLP:lidocaine hydrochloride