Home›Fluvoxamine›Fluvoxamine + Tizanidne Hydrochloride

Does Fluvoxamine Interact with Tizanidne Hydrochloride?

Fluvoxamine and Tizanidne Hydrochloride have a contraindicated drug interaction according to U.S. FDA drug labeling data. Strong CYP1A2 inhibitor; concomitant use contraindicated due to significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment. The mechanism involves inhibition of cyp1a2 metabolism of tizanidine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Fluvoxamine and Tizanidne Hydrochloride occurs because inhibition of cyp1a2 metabolism of tizanidine. Clinically, this means strong cyp1a2 inhibitor; concomitant use contraindicated due to significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Fluvoxamine and your doctor is considering prescribing Tizanidne Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fluvoxamine+💊 Tizanidne Hydrochloride(Tizanidne Hydrochloride)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:tizanidne hydrochloride

What this means in plain English

Strong CYP1A2 inhibitor; concomitant use contraindicated due to significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment.

What the FDA label says

"Inhibition of CYP1A2 metabolism of tizanidine"

📖 Source: NLP:tizanidne hydrochloride

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Fluvoxamine and Tizanidne Hydrochloride against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.