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Does Glipizide And Metformin Hydrochloride Interact with Oral Miconazole?

Glipizide And Metformin Hydrochloride and Oral Miconazole have a major drug interaction according to U.S. FDA drug labeling data. Potential interaction with oral miconazole leading to severe hypoglycemia has been reported. Effect of intravenous, topical, or vaginal preparations is not known. The mechanism involves potentiation of hypoglycemic action. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Glipizide And Metformin Hydrochloride Class
Sulfonylurea
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Glipizide And Metformin Hydrochloride and Oral Miconazole occurs because potentiation of hypoglycemic action. Clinically, this means potential interaction with oral miconazole leading to severe hypoglycemia has been reported. effect of intravenous, topical, or vaginal preparations is not known. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Glipizide And Metformin Hydrochloride and your doctor is considering prescribing Oral Miconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Glipizide And Metformin Hydrochloride(Glipizide And Metformin Hydrochloride)+💊 Oral Miconazole

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Sulfonylurea
Drug B class
—
Source
NLP:glipizide and metformin hydrochloride

What this means in plain English

Potential interaction with oral miconazole leading to severe hypoglycemia has been reported. Effect of intravenous, topical, or vaginal preparations is not known.

What the FDA label says

"Potentiation of hypoglycemic action"

📖 Source: NLP:glipizide and metformin hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.