Does Glipizide And Metformin Hydrochloride Interact with Fluconazole?
CDI records a major classification for Glipizide And Metformin Hydrochloride and Fluconazole. The stored summary is: Fluconazole increases glipizide AUC by a mean of 56.9%, potentially increasing hypoglycemic effect. Patient should be observed closely for hypoglycemia. The mechanism involves increased glipizide plasma levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Glipizide And Metformin Hydrochloride Class
- Sulfonylurea
- Fluconazole Class
- Azole Antifungal
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased glipizide plasma levels
What To Tell Your Doctor or Pharmacist
If you are taking Glipizide And Metformin Hydrochloride and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider