Does Glipizide And Metformin Hydrochloride Interact with Tolbutamide?
Glipizide And Metformin Hydrochloride and Tolbutamide have a unknown drug interaction according to U.S. FDA drug labeling data. In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Glipizide And Metformin Hydrochloride Class
- Sulfonylurea
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Glipizide And Metformin Hydrochloride and your doctor is considering prescribing Tolbutamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider