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Does Grapefruit Products Interact with Suzetrigine?

Grapefruit Products and Suzetrigine have a major drug interaction according to U.S. FDA drug labeling data. Food or drink containing grapefruit should be avoided during treatment with JOURNAVX. Grapefruit inhibits CYP3A, increasing suzetrigine exposure. The mechanism involves grapefruit is a cyp3a inhibitor that increases suzetrigine and m6-suz exposures. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Suzetrigine Class
Sodium Channel Blocker
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Grapefruit Products and Suzetrigine occurs because grapefruit is a cyp3a inhibitor that increases suzetrigine and m6-suz exposures. Clinically, this means food or drink containing grapefruit should be avoided during treatment with journavx. grapefruit inhibits cyp3a, increasing suzetrigine exposure. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Grapefruit Products and your doctor is considering prescribing Suzetrigine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Grapefruit Products+💊 Suzetrigine(Journavx)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Sodium Channel Blocker
Source
NLP:suzetrigine

What this means in plain English

Food or drink containing grapefruit should be avoided during treatment with JOURNAVX. Grapefruit inhibits CYP3A, increasing suzetrigine exposure.

What the FDA label says

"Grapefruit is a CYP3A inhibitor that increases suzetrigine and M6-SUZ exposures"

📖 Source: NLP:suzetrigine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.