Hydantoins + Liothyronine Sodium Interaction
Moderateinteraction on record
Description
May cause protein binding site displacement. Phenytoin reduces serum protein binding of thyroid hormones, with total and FT4 reduced 20-40%, but most patients remain clinically euthyroid. Closely monitor thyroid parameters.
Mechanism
Reduced serum protein binding of thyroid hormones
Source: NLP:liothyronine sodium