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Does Hydralazine Hydrochloride And Isosorbide Dinitrate Interact with Tadalafil?

Hydralazine Hydrochloride And Isosorbide Dinitrate and Tadalafil have a contraindicated drug interaction according to U.S. FDA drug labeling data. PDE5 inhibitor potentiates hypotensive effects of isosorbide dinitrate. Contraindicated. The mechanism involves potentiation of hypotensive effects via pde5 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Hydralazine Hydrochloride And Isosorbide Dinitrate Class
Nitrate Vasodilator
Tadalafil Class
Phosphodiesterase 5 Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Hydralazine Hydrochloride And Isosorbide Dinitrate and Tadalafil occurs because potentiation of hypotensive effects via pde5 inhibition. Clinically, this means pde5 inhibitor potentiates hypotensive effects of isosorbide dinitrate. contraindicated. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Hydralazine Hydrochloride And Isosorbide Dinitrate and your doctor is considering prescribing Tadalafil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Hydralazine Hydrochloride And Isosorbide Dinitrate(Bidil)+💊 Tadalafil(Alyq)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Nitrate Vasodilator
Drug B class
Phosphodiesterase 5 Inhibitor
Source
NLP:hydralazine hydrochloride and isosorbide dinitrate

What this means in plain English

PDE5 inhibitor potentiates hypotensive effects of isosorbide dinitrate. Contraindicated.

About Hydralazine Hydrochloride And Isosorbide Dinitrate and Tadalafil

Hydralazine Hydrochloride And Isosorbide Dinitrate is a Nitrate Vasodilator, while Tadalafil is a Phosphodiesterase 5 Inhibitor. You may recognize them by the brand names Bidil and Alyq. Both medications are taken by mouth. Tadalafil additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Potentiation of hypotensive effects via PDE5 inhibition"

📖 Source: NLP:hydralazine hydrochloride and isosorbide dinitrate

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.