Does Hydrochlorothiazide Interact with Amantadine?
CDI records a moderate classification for Hydrochlorothiazide and Amantadine. The stored summary is: Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels. The mechanism involves may reduce renal clearance of amantadine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Moderate
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Amantadine Class
- Influenza A M2 Protein Inhibitor
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
May reduce renal clearance of amantadine
What To Tell Your Doctor or Pharmacist
If you are taking Hydrochlorothiazide and your doctor is considering prescribing Amantadine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider