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Does Hydrochlorothiazide Interact with Febuxostat Tablets 40 Mg?

Hydrochlorothiazide and Febuxostat Tablets 40 Mg have a unknown drug interaction according to U.S. FDA drug labeling data. 7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology ( 12.3 )]. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Hydrochlorothiazide Class
Thiazide Diuretic
Febuxostat Tablets 40 Mg Class
Xanthine Oxidase Inhibitor
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Hydrochlorothiazide and your doctor is considering prescribing Febuxostat Tablets 40 Mg (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Hydrochlorothiazide+💊 Febuxostat Tablets 40 Mg(Febuxostat)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
Xanthine Oxidase Inhibitor
Source
FDA drug label - febuxostat tablets 40 mg

What this means in plain English

7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology ( 12.3 )].

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.