Does Hydrochlorothiazide Interact with Irbesartan?
Hydrochlorothiazide and Irbesartan have a minor drug interaction according to U.S. FDA drug labeling data. Irbesartan administration for 7 days had no effect on the pharmacokinetics of hydrochlorothiazide. Pharmacokinetics of irbesartan were not affected by coadministration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Irbesartan Class
- Angiotensin 2 Receptor Blocker
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Hydrochlorothiazide and your doctor is considering prescribing Irbesartan (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider