Does Hydrocodone Interact with Midazolam?
Hydrocodone and Midazolam have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use increases risk of respiratory depression through actions at different CNS receptor sites. The mechanism involves combined cns depression at gaba-a and mu receptors. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Midazolam Class
- Benzodiazepine
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Hydrocodone and Midazolam occurs because combined cns depression at gaba-a and mu receptors. Clinically, this means concomitant use increases risk of respiratory depression through actions at different cns receptor sites. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Hydrocodone and your doctor is considering prescribing Midazolam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider