Does Indocyanine Green Interact with Radioactive Iodine?
Indocyanine Green and Radioactive Iodine have a moderate drug interaction according to U.S. FDA drug labeling data. IC-GREEN contains sodium iodide which reduces iodine-binding capacity of thyroid tissue for at least one week, interfering with radioactive iodine uptake studies. Do not perform studies within one week of IC-GREEN administration. The mechanism involves reduced iodine-binding capacity of thyroid tissue due to sodium iodide content. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Indocyanine Green and Radioactive Iodine occurs because reduced iodine-binding capacity of thyroid tissue due to sodium iodide content. Clinically, this means ic-green contains sodium iodide which reduces iodine-binding capacity of thyroid tissue for at least one week, interfering with radioactive iodine uptake studies. do not perform studies within one week of ic-green administration. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Indocyanine Green and your doctor is considering prescribing Radioactive Iodine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider