Does Iobenguane I 123 Interact with Labetalol?
Iobenguane I 123 and Labetalol have a moderate drug interaction according to U.S. FDA drug labeling data. Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and causing false negative imaging results. The mechanism involves depletion of norepinephrine stores or inhibition of reuptake. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Labetalol Class
- beta-Adrenergic Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Iobenguane I 123 and Labetalol occurs because depletion of norepinephrine stores or inhibition of reuptake. Clinically, this means antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and causing false negative imaging results. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Iobenguane I 123 and your doctor is considering prescribing Labetalol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider