Does Ixabepilone Interact with Capecitabine?
Ixabepilone and Capecitabine have a minor drug interaction according to U.S. FDA drug labeling data. No clinically meaningful pharmacokinetic differences observed. Ixabepilone Cmax decreased 19%, capecitabine Cmax decreased 27%, 5-fluorouracil AUC increased 14%; interaction not clinically significant given supported efficacy data. The mechanism involves mutual pharmacokinetic effects with minimal clinical impact. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Capecitabine Class
- Nucleoside Metabolic Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ixabepilone and Capecitabine occurs because mutual pharmacokinetic effects with minimal clinical impact. Clinically, this means no clinically meaningful pharmacokinetic differences observed. ixabepilone cmax decreased 19%, capecitabine cmax decreased 27%, 5-fluorouracil auc increased 14%; interaction not clinically significant given supported efficacy data. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Ixabepilone and your doctor is considering prescribing Capecitabine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider