Does Ketoconazole Interact with Omeprazole And Sodium Bicarbonate?
Ketoconazole and Omeprazole And Sodium Bicarbonate have a moderate drug interaction according to U.S. FDA drug labeling data. Omeprazole and sodium bicarbonate may reduce absorption of ketoconazole by decreasing gastric pH. The mechanism involves decreased gastric acidity reduces drug bioavailability. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Ketoconazole Class
- Azole Antifungal
- Omeprazole And Sodium Bicarbonate Class
- Proton Pump Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ketoconazole and Omeprazole And Sodium Bicarbonate occurs because decreased gastric acidity reduces drug bioavailability. Clinically, this means omeprazole and sodium bicarbonate may reduce absorption of ketoconazole by decreasing gastric ph. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ketoconazole and your doctor is considering prescribing Omeprazole And Sodium Bicarbonate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider